Authors:
Canive M, Fernandez-Jimenez N, Casais R, Vázquez P, Lavín JL, Bilbao JR, Blanco-Vázquez C, Garrido JM, Juste RA, Alonso-Hearn M
(Contact: malonso@neiker.eus )
Affiliation:
Department of Animal Health, NEIKER- Basque Research and Technology Alliance (BRTA), Derio, Bizkaia, Spain
Title:
Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression
Journal:
Scientific Reports, 11(1): 313 (2021)
DOI :
10.1038/s41598-020-79619-x
Links:
PubMed | Abstract
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( Related study: none )
Click on each trait to browse further along the related trait ontology tree
Click on each chromosome number to find the detailed QTL information on that chromosome
Number of QTL/association reported by traits:
QTL/association Reported by chromosomes:
Number of gene-based eQTL/associations:
eQTL for aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)-like (LOC538060) :Chr.1 : eQTL:223019 ; eQTL for MDS1 and EVI1 complex locus (MECOM) :Chr.1 : eQTL:222892 ; eQTL for proteasome assembly chaperone 1 (PSMG1) :Chr.1 : eQTL:222945 ; eQTL for thrombospondin type laminin G domain and EAR repeats (TSPEAR) :Chr.1 : eQTL:222980 ; eQTL for glutathione peroxidase 5 (GPX5) :Chr.1 : eQTL:222929 ; eQTL for karyopherin subunit alpha 6 (KPNA6) :Chr.1 : eQTL:222876 ; eQTL for phosphofructokinase, liver type (PFKL) :Chr.1 : eQTL:222922 ; eQTL for autoimmune regulator (AIRE) :Chr.1 : eQTL:223065 ; eQTL for WD repeat domain 49 (WDR49) :Chr.1 : eQTL:223005 ; eQTL for S100 calcium binding protein B (S100B) :Chr.1 : eQTL:222888 ; eQTL for peptidyl arginine deiminase 1 (PADI1) :Chr.2 : eQTL:223039 ; eQTL for spermatogenesis associated 21 (SPATA21) :Chr.2 : eQTL:222940 ; eQTL for taste receptor, type 1, member 2 (TAS1R2) :Chr.2 : eQTL:222956 ; eQTL for chimerin 1 (CHN1) :Chr.2 : eQTL:222906 ; eQTL for small Cajal body-specific RNA 1 (LOC112443661) :Chr.2 : eQTL:223029 ; eQTL for desmin (DES) :Chr.2 : eQTL:222891 ; eQTL for transcription elongation factor A3 (TCEA3) :Chr.2 : eQTL:223012 ; eQTL for atypical chemokine receptor 3 (ACKR3) :Chr.3 : eQTL:222976 ; eQTL for CD5 molecule like (CD5L) :Chr.3 : eQTL:222998 ; eQTL for latrophilin 2 (LPHN2) :Chr.3 : eQTL:222930 ; eQTL for peroxiredoxin 1 (PRDX1) :Chr.3 : eQTL:223041 ; eQTL for ATPase Na+/K+ transporting subunit alpha 2 (ATP1A2) :Chr.3 : eQTL:222921 ; eQTL for spermatogenesis associated 46 (SPATA46) :Chr.3 : eQTL:222917 ; eQTL for U6 spliceosomal RNA (LOC112446079) :Chr.3 : eQTL:223020 ; eQTL for calsequestrin 1 (CASQ1) :Chr.3 : eQTL:222987 ; eQTL for zinc finger protein 684 (ZNF684) :Chr.3 : eQTL:222855 ; eQTL for solute carrier family 2 member 1 (SLC2A1) :Chr.3 : eQTL:222914 ; eQTL for G protein-coupled receptor 141 (GPR141) :Chr.4 : eQTL:222872 ; eQTL for neuronal cell adhesion molecule (NRCAM) :Chr.4 : eQTL:222897 ; eQTL for amphiphysin (AMPH) :Chr.4 : eQTL:223006 ; eQTL for neuropeptide Y (NPY) :Chr.4 : eQTL:223043 ; eQTL for diacylglycerol kinase beta (DGKB) :Chr.4 : eQTL:222995 ; eQTL for small nucleolar RNA SNORA11 (LOC112446877) :Chr.5 : eQTL:223022 ; eQTL for U12 minor spliceosomal RNA (LOC112446886) :Chr.5 : eQTL:223011 ; eQTL for PHD finger protein 21B (PHF21B) :Chr.5 : eQTL:222901 ; eQTL for Y-box binding protein 3 (YBX3) :Chr.5 : eQTL:222915 ; eQTL for Wnt family member 1 (WNT1) :Chr.5 : eQTL:223056 ; eQTL for beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (MGAT3) :Chr.5 : eQTL:222935 ; eQTL for meiotic double-stranded break formation protein 1 (MEI1) :Chr.5 : eQTL:222884 ; eQTL for synaptonemal complex protein 3 (SYCP3) :Chr.5 : eQTL:222875 ; eQTL for C-type lectin domain family 12 member B (CLEC12B) :Chr.5 : eQTL:222881 ; eQTL for Kv channel interacting protein 4 (KCNIP4) :Chr.6 : eQTL:223079 ; eQTL for epiregulin (EREG) :Chr.6 : eQTL:222918 ; eQTL for olfactory receptor family 2 subfamily C member 3 (OR2C3) :Chr.7 : eQTL:223082 ; eQTL for olfactory receptor family 2 subfamily C member 3B (OR2C3B) :Chr.7 : eQTL:223081 ; eQTL for early growth response 1 (EGR1) :Chr.7 : eQTL:222916 ; eQTL for alkaline ceramidase 1 (ACER1) :Chr.7 : eQTL:222907 ; eQTL for paired like homeodomain 1 (PITX1) :Chr.7 : eQTL:222887 ; eQTL for fibrillin 2 (FBN2) :Chr.7 : eQTL:222959 ; eQTL for complement C3 (C3) :Chr.7 : eQTL:222970 ; eQTL for obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN) :Chr.7 : eQTL:223017 ; eQTL for FHF complex subunit HOOK interacting protein 2B (FHIP2B) :Chr.8 : eQTL:223055 ; eQTL for U1 spliceosomal RNA (LOC112447937) :Chr.8 : eQTL:223070 ; eQTL for FYVE, RhoGEF and PH domain containing 3 (FGD3) :Chr.8 : eQTL:222899 ; eQTL for tenascin C (TNC) :Chr.8 : eQTL:222856 ; eQTL for palladin, cytoskeletal associated protein (PALLD) :Chr.8 : eQTL:222863 ; eQTL for NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa pseudogene (LOC785629) :Chr.8 : eQTL:223080 ; eQTL for claudin 20 (CLDN20) :Chr.9 : eQTL:223075 ; eQTL for ryanodine receptor 3 (RYR3) :Chr.10 : eQTL:223003 ; eQTL for coiled-coil domain containing 196 (CCDC196) :Chr.10 : eQTL:223054 ; eQTL for tau tubulin kinase 2 (TTBK2) :Chr.10 : eQTL:222895 ; eQTL for arylsulfatase B (ARSB) :Chr.10 : eQTL:223046 ; eQTL for protogenin (PRTG) :Chr.10 : eQTL:223044 ; eQTL for small nucleolar RNA SNORA41 (LOC112448612) :Chr.10 : eQTL:223074 ; eQTL for progestin and adipoQ receptor family member 5 (PAQR5) :Chr.10 : eQTL:222989 ; eQTL for ZFP36 ring finger protein like 1 (ZFP36L1) :Chr.10 : eQTL:223001 ; eQTL for n/asmall nucleolar RNA SNORA42/SNORA80 family (LOC112448922) :Chr.11 : eQTL:223034 ; eQTL for neuralized E3 ubiquitin protein ligase 3 (NEURL3) :Chr.11 : eQTL:223040 ; eQTL for sprouty related EVH1 domain containing 2 (SPRED2) :Chr.11 : eQTL:222984 ; eQTL for glutamine--fructose-6-phosphate transaminase 1 (GFPT1) :Chr.11 : eQTL:222972 ; eQTL for MORN repeat containing 5 (MORN5) :Chr.11 : eQTL:223042 ; eQTL for StAR related lipid transfer domain containing 7 (STARD7) :Chr.11 : eQTL:222975 ; eQTL for prominin 2 (PROM2) :Chr.11 : eQTL:223038 ; eQTL for HCLS1 binding protein 3 (HS1BP3) :Chr.11 : eQTL:222962 ; eQTL for odd-skipped related transcription factor 1 (OSR1) :Chr.11 : eQTL:223045 ; eQTL for fms related receptor tyrosine kinase 3 (FLT3) :Chr.12 : eQTL:222978 ; eQTL for protocadherin 8 (PCDH8) :Chr.12 : eQTL:222974 ; eQTL for coiled-coil domain containing 70 (CCDC70) :Chr.12 : eQTL:222985 ; eQTL for lipopolysaccharide binding protein (LBP) :Chr.13 : eQTL:222968 ; eQTL for eukaryotic translation elongation factor 1 alpha 2 (EEF1A2) :Chr.13 : eQTL:222994 ; eQTL for junctional cadherin 5 associated (JCAD) :Chr.13 : eQTL:222866 ; eQTL for uncharacterized LOC100196900 (LOC100196900) :Chr.13 : eQTL:223032 ; eQTL for BPI fold containing family A, member 2B (BPIFA2B) :Chr.13 : eQTL:223062 ; eQTL for adipogenin (ADIG) :Chr.13 : eQTL:223071 ; eQTL for PR/SET domain 14 (PRDM14) :Chr.14 : eQTL:222852 ; eQTL for solute carrier organic anion transporter family member 5A1 (SLCO5A1) :Chr.14 : eQTL:223008 ; eQTL for adenylate cyclase 8 (ADCY8) :Chr.14 : eQTL:222951 ; eQTL for recombination activating 2 (RAG2) :Chr.15 : eQTL:223072 ; eQTL for Rho GTPase activating protein 20 (ARHGAP20) :Chr.15 : eQTL:222854 ; eQTL for ribosomal RNA processing 8 (RRP8) :Chr.15 : eQTL:222860 ; eQTL for apolipoprotein A4 (APOA4) :Chr.15 : eQTL:223063 ; eQTL for SET binding factor 2 (SBF2) :Chr.15 : eQTL:223025 ; eQTL for VPS26, retromer complex component B (VPS26B) :Chr.15 : eQTL:222952 ; eQTL for C1q and TNF related 5 (C1QTNF5) :Chr.15 : eQTL:223004 ; eQTL for adrenomedullin (ADM) :Chr.15 : eQTL:222992 ; eQTL for calpain 5 (CAPN5) :Chr.15 : eQTL:222889 ; eQTL for ferritin heavy chain 1 pseudogene (LOC782705) :Chr.15 : eQTL:222912 ; eQTL for inositol 1,4,5-triphosphate receptor associated 1 (IRAG1) :Chr.15 : eQTL:222902 ; eQTL for apolipoprotein C3 (APOC3) :Chr.15 : eQTL:223049 ; eQTL for dickkopf WNT signaling pathway inhibitor 3 (DKK3) :Chr.15 : eQTL:222880 ; eQTL for myelin protein zero like 2 (MPZL2) :Chr.15 : eQTL:223009 ; eQTL for leiomodin 1 (LMOD1) :Chr.16 : eQTL:222993 ; eQTL for BMP/retinoic acid inducible neural specific 2 (BRINP2) :Chr.16 : eQTL:222946 ; eQTL for N-acetylneuraminate pyruvate lyase (NPL) :Chr.16 : eQTL:222874 ; eQTL for calpain 2, (m/II) large subunit (CAPN2) :Chr.16 : eQTL:222937 ; eQTL for arylacetamide deacetylase like 3 (AADACL3) :Chr.16 : eQTL:223057 ; eQTL for prostaglandin-endoperoxide synthase 2 (PTGS2) :Chr.16 : eQTL:223052 ; eQTL for selectin E (SELE) :Chr.16 : eQTL:222904 ; eQTL for PPARGC1 and ESRR induced regulator, muscle 1 (PERM1) :Chr.16 : eQTL:222950 ; eQTL for SEC16 homolog B, endoplasmic reticulum export factor (SEC16B) :Chr.16 : eQTL:222862 ; eQTL for nitric oxide synthase 1 (NOS1) :Chr.17 : eQTL:222871 ; eQTL for phospholipase A2 group III (PLA2G3) :Chr.17 : eQTL:222928 ; eQTL for phospholipase A2 group IB (PLA2G1B) :Chr.17 : eQTL:223067 ; eQTL for sialic acid-binding Ig-like lectin 14 (LOC789748) :Chr.18 : eQTL:222983 ; eQTL for metallothionein 1E (MT1E) :Chr.18 : eQTL:223037 ; eQTL for engulfment and cell motility 3 (ELMO3) :Chr.18 : eQTL:222868 ; eQTL for testis expressed 101 (TEX101) :Chr.18 : eQTL:222967 ; eQTL for fat mass and obesity associated (FTO) :Chr.18 : eQTL:222932 ; eQTL for myosin XIX (MYO19) :Chr.19 : eQTL:222936 ; eQTL for galectin 9 (LGALS9) :Chr.19 : eQTL:222898 ; eQTL for microRNA mir-451 (MIR451) :Chr.19 : eQTL:223010 ; eQTL for collagen type I alpha 1 chain (COL1A1) :Chr.19 : eQTL:222939 ; eQTL for lactoperoxidase (LPO) :Chr.19 : eQTL:222938 ; eQTL for HID1 domain containing (HID1) :Chr.19 : eQTL:222923 ; eQTL for potassium voltage-gated channel subfamily H member 4 (KCNH4) :Chr.19 : eQTL:222865 ; eQTL for calcium voltage-gated channel auxiliary subunit gamma 1 (CACNG1) :Chr.19 : eQTL:222905 ; eQTL for vitronectin (VTN) :Chr.19 : eQTL:222964 ; eQTL for phosphodiesterase 6G (PDE6G) :Chr.19 : eQTL:223036 ; eQTL for TLC domain containing 2 (TLCD2) :Chr.19 : eQTL:223048 ; eQTL for cadherin 9 (CDH9) :Chr.20 : eQTL:223061 ; eQTL for iroquois homeobox 2 (IRX2) :Chr.20 : eQTL:223078 ; eQTL for ADAM metallopeptidase with thrombospondin type 1 motif 7 (ADAMTS7) :Chr.21 : eQTL:222870 ; eQTL for cathepsin G (LOC505658) :Chr.21 : eQTL:223073 ; eQTL for duodenase-1-like (LOC786126) :Chr.21 : eQTL:223050 ; eQTL for aggrecan (ACAN) :Chr.21 : eQTL:223060 ; eQTL for tetratricopeptide repeat domain 23 (TTC23) :Chr.21 : eQTL:222924 ; eQTL for NOVA alternative splicing regulator 1 (NOVA1) :Chr.21 : eQTL:222873 ; eQTL for aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) :Chr.21 : eQTL:222931 ; eQTL for neurotrophic receptor tyrosine kinase 3 (NTRK3) :Chr.21 : eQTL:223035 ; eQTL for cholinergic receptor, nicotinic, alpha 7 (CHRNA7) :Chr.21 : eQTL:223059 ; eQTL for selenoprotein S (SELENOS) :Chr.21 : eQTL:222857 ; eQTL for myosin light chain 3 (MYL3) :Chr.22 : eQTL:222911 ; eQTL for musculoskeletal, embryonic nuclear protein 1 (MUSTN1) :Chr.22 : eQTL:223007 ; eQTL for zinc finger protein 311 (ZNF311) :Chr.23 : eQTL:222910 ; eQTL for cap methyltransferase 1 (CMTR1) :Chr.23 : eQTL:222969 ; eQTL for kinesin family member 6 (KIF6) :Chr.23 : eQTL:223068 ; eQTL for zinc finger and BTB domain containing 14 (ZBTB14) :Chr.24 : eQTL:223014 ; eQTL for cerebellin 2 precursor (CBLN2) :Chr.24 : eQTL:222894 ; eQTL for desmoglein 2 (DSG2) :Chr.24 : eQTL:222996 ; eQTL for lipoxygenase homology PLAT domains 1 (LOXHD1) :Chr.24 : eQTL:222954 ; eQTL for phosphorylase kinase catalytic subunit gamma 1 (PHKG1) :Chr.25 : eQTL:222908 ; eQTL for linker for activation of T cells family member 2 (LAT2) :Chr.25 : eQTL:223031 ; eQTL for ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 (ATP2A1) :Chr.25 : eQTL:222896 ; eQTL for proline rich acidic protein 1 (PRAP1) :Chr.26 : eQTL:222947 ; eQTL for DNA nucleotidylexotransferase (DNTT) :Chr.26 : eQTL:222990 ; eQTL for period circadian regulator 1 (PER1) :Chr.26 : eQTL:222878 ; eQTL for small nucleolar RNA SNORA79 (LOC112444564) :Chr.26 : eQTL:223030 ; eQTL for BCL2 interacting protein 3 (BNIP3) :Chr.26 : eQTL:222973 ; eQTL for DLC1 Rho GTPase activating protein (DLC1) :Chr.27 : eQTL:222963 ; eQTL for microtubule associated scaffold protein 1 (MTUS1) :Chr.27 : eQTL:223015 ; eQTL for ankyrin repeat domain 37 (ANKRD37) :Chr.27 : eQTL:222977 ; eQTL for actinin alpha 2 (ACTN2) :Chr.28 : eQTL:223047 ; eQTL for potassium two pore domain channel subfamily K member 16 (KCNK16) :Chr.29 : eQTL:222919 ; eQTL for cysteine and glycine rich protein 3 (CSRP3) :Chr.29 : eQTL:222927 ; eQTL for thyroid hormone responsive (THRSP) :Chr.29 : eQTL:222926 ; eQTL for protein tyrosine phosphatase non-receptor type 5 (PTPN5) :Chr.29 : eQTL:222988 ; eQTL for hepatic and glial cell adhesion molecule (HEPACAM) :Chr.29 : eQTL:222981 ; eQTL for troponin T3, fast skeletal type (TNNT3) :Chr.29 : eQTL:222997 ;
eQTL by their cis/trans acting types:
Cis eQTL:
222852 , 222853 , 222854 , 222855 , 222856 , 222857 , 222858 , 222859 , 222860 , 222861 , 222862 , 222863 , 222864 , 222865 , 222866 , 222867 , 222868 , 222869 , 222870 , 222871 , 222872 , 222873 , 222874 , 222875 , 222876 , 222877 , 222878 , 222879 , 222880 , 222881 , 222882 , 222883 , 222884 , 222885 , 222886 , 222887 , 222888 , 222889 , 222890 , 222891 , 222892 , 222893 , 222894 , 222895 , 222896 , 222897 , 222898 , 222899 , 222900 , 222901 , 222902 , 222903 , 222904 , 222905 , 222906 , 222907 , 222908 , 222909 , 222910 , 222911 , 222912 , 222913 , 222914 , 222915 , 222916 , 222917 , 222918 , 222919 , 222920 , 222921 , 222922 , 222923 , 222924 , 222925 , 222926 , 222927 , 222928 , 222929 , 222930 , 222931 , 222932 , 222933 , 222934 , 222935 , 222936 , 222937 , 222938 , 222939 , 222940 , 222941 , 222942 , 222943 , 222944 , 222945 , 222946 , 222947 , 222948 , 222949 , 222950 , 222951 , 222952 , 222953 , 222954 , 222955 , 222956 , 222957 , 222958 , 222959 , 222960 , 222961 , 222962 , 222963 , 222964 , 222965 , 222966 , 222967 , 222968 , 222969 , 222970 , 222971 , 222972 , 222973 , 222974 , 222975 , 222976 , 222977 , 222978 , 222979 , 222980 , 222981 , 222982 , 222983 , 222984 , 222985 , 222986 , 222987 , 222988 , 222989 , 222990 , 222991 , 222992 , 222993 , 222994 , 222995 , 222996 , 222997 , 222998 , 222999 , 223000 , 223001 , 223002 , 223003 , 223004 , 223005 , 223006 , 223007 , 223008 , 223009 , 223010 , 223011 , 223012 , 223013 , 223014 , 223015 , 223016 , 223017 , 223018 , 223019 , 223020 , 223021 , 223022 , 223023 , 223024 , 223025 , 223026 , 223027 , 223028 , 223029 , 223030 , 223031 , 223032 , 223033 , 223034 , 223035 , 223036 , 223037 , 223038 , 223039 , 223040 , 223041 , 223042 , 223043 , 223044 , 223045 , 223046 , 223047 , 223048 , 223049 , 223050 , 223051 , 223052 , 223053 , 223054 , 223055 , 223056 , 223057 , 223058 , 223059 , 223060 , 223061 , 223062 , 223063 , 223064 , 223065 , 223066 , 223067 , 223068 , 223069 , 223070 , 223071 , 223072 , 223073 , 223074 , 223075 , 223076 , 223077 , 223078 , 223079 , 223080 , 223081 , 223082 .
Cite this Dataset :
Animal QTLdb: Dataset from Canive M, Fernandez-Jimenez N, Casais R, Vázquez P, Lavín JL, Bilbao JR, Blanco-Vázquez C, Garrido JM, Juste RA, Alonso-Hearn M (2021). Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression. Scientific reports, 11(1): 313;
Curated into QTLdb on 2021-06-10. Universal link to this data set:
https://www.animalgenome.org/QTLdb/supp/?t=KrTq4F9QaR
OR
Canive M, Fernandez-Jimenez N, Casais R, Vázquez P, Lavín JL, Bilbao JR, Blanco-Vázquez C, Garrido JM, Juste RA, Alonso-Hearn M (2021). Identification of loci associated with susceptibility to bovine paratuberculosis and with the dysregulation of the MECOM, eEF1A2, and U1 spliceosomal RNA expression. Scientific reports, 11(1): 313; DOI: https://dx.doi.org/10.1038/s41598-020-79619-x