| QTL Map Information |
|---|
| Chromosome: | 19 |
| QTL Peak Location: | 60.35 (cM) |
| QTL Span: | 60.35-60.35 (cM)
32.9-32.9 (Mbp) |
 |
Upper, "Suggestive": | n/a |
| Upper, "Significant": | n/a |
| Peak: | rs109898712 |
| Lower, "Significant": | n/a |
| Lower, "Suggestive": | n/a |
| Marker type: | SNP |
| Analysis type: | Association |
| Model tested: | Mendelian |
| Test base: | Comparison-wise |
| Threshold significance level: | Significant |
 |
P_values | 5.19E-15 | | Dominance effect: | n/a |
| Additive effect: | n/a |
| Associated Gene: | n/a |
| Cis/Trans acting type: |  |
| Links:
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| Extended information: |
|---|
| (none) |
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| QTL Experiment in Brief |
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| Animals: | Cattle were Holstein-Friesian and Jersey and their crosses. |
| Breeds associated:
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| Design: | Animals were genotyped using the Illumina Bovine SNP50 BeadChip or GeneSeek Genomic Profiler BeadChip, with data imputed to higher density using RNAseq alignments, and analyzed for milk lactose traits. Then, 1 Mbp windows centered on the top QTL markers were imputed to whole-genome sequence resolution for further analysis. |
| Analysis: | Generalized least squares models were used. |
| Software: | GCTA, Samtools, Beagle 4, GATK HaplotypeCaller, PLINK |
| Notes: | |
| Links: | Edit |
| Reference |
|---|
| Authors: | Lopdell TJ, Tiplady K, Struchalin M, Johnson TJJ, Keehan M, Sherlock R, Couldrey C, Davis SR, Snell RG, Spelman RJ, Littlejohn MD |
| Affiliation: | Research and Development, Livestock Improvement Corporation, Ruakura Road, Newstead, Hamilton, New Zealand |
| Title: | DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content |
| Journal: | BMC genomics, 2017, 18(1): 968 |
| Links: |
PubMed | Abstract | List all data
| Edit |
| Additional Information |
|---|
| Comments: | HD & RNA-seq variant sets |
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